| Sonntag 22. April 2018 | |||||
| 20:00 | FC Granada |  | 3 - 3 |  | Cultural Leonesa |
| 18:00 | Cádiz |  | 0 - 0 |  | Sporting Gijón |
| 18:00 | Lugo |  | 1 - 1 |  | Lorca |
| 16:00 | Barcelona II |  | 2 - 3 |  | Rayo Vallecano |
| 12:00 | Alcorcón |  | 0 - 0 |  | CA Osasuna |
| Sonnabend 21. April 2018 | |||||
| 18:00 | Albacete Balompie |  | 0 - 1 |  | Reus Deportiu |
| 18:00 | CD Teneriffa |  | 2 - 4 |  | Huesca |
| 16:00 | Gimnàstic Tarragona |  | 0 - 0 |  | Numancia |
| 16:00 | Real Saragossa |  | 2 - 1 |  | Almería |
| Freitag 20. April 2018 | |||||
| 21:00 | Real Oviedo |  | 1 - 2 |  | Real Valladolid |
| 21:00 | Córdoba |  | 3 - 0 |  | Sevilla II |
