| Sonntag 14. Oktober 2018 | |||||
| 20:45 | FC Granada |  | 1 - 0 |  | RCD Mallorca |
| 16:00 | Rayo Majadahonda |  | 1 - 0 |  | Real Oviedo |
| 13:00 | CD Teneriffa |  | 0 - 0 |  | Lugo |
| Sonnabend 13. Oktober 2018 | |||||
| 20:30 | Almería |  | 3 - 0 |  | UD Las Palmas |
| 20:30 | Numancia |  | 1 - 0 |  | Real Saragossa |
| 18:00 | Sporting Gijón |  | 1 - 1 |  | Reus Deportiu |
| 16:00 | CA Osasuna |  | 3 - 1 |  | Córdoba |
| Freitag 12. Oktober 2018 | |||||
| 21:00 | Deportivo La Coruña |  | 4 - 0 |  | FC Elche |
| 18:00 | Extremadura UD |  | 2 - 1 |  | Cádiz |
| 16:00 | FC Málaga |  | 2 - 1 |  | Albacete Balompie |
